Go inside the high-security lab where scientists search for a coronavirus vaccine

A day at the office for virologist Darryl Falzaranoincludes donning two layersof rubber gloves, a sealed body suit and an astronaut-like helmet, then taking a shower every time he steps outside the lab.

The strict safety protocols are necessary to handle potentially lethal pathogens, and to develop vaccines that could stop them.

Falzarano is the lead investigator for a Saskatoon team tackling the coronavirus that originated in Wuhan, China, last month.Ithas infected almost 6,000 people, and killedmore than 130, and has spread to more than a dozen countriesincluding Canada.

In a rare opportunity, Falzarano escorted CBCNews inside a containment lab at the Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac) on the University of Saskatchewan campus. VIDO-InterVacisone of the largest, most advanced infectious disease research sites in the world and the lab is in the second-highest category of safety; biosafetylevel 3is for work involving microbes that can cause serious and potentially lethal disease by inhalation.

Researchers have already started preliminary work on a vaccine, using what they've learned in the past from other strains of coronaviruses.

The handful of new coronavirus cases in Canada will likely speed up their work,Falzarano says.VIDO-InterVachas requested a sample from the Public Health Agency of Canada and Public Health Ontario.

Researchers also ordered ingredients to build their ownsynthetic version of the coronavirus, using genome sequencing information fromChina. But making their own would take weeks.

Getting a sample of the virus "is a lot faster than reconstructing it ourselves," Falzarano said.

His goal is to create a vaccine prototype within six to eight weeks, to be followed by animal testing.

Inside the lab: Scientists tackle vaccine for novel coronavirus in high security lab

5 years ago

Duration 2:34

Scientists at a Saskatoon lab are part of a global effort to find a vaccine for the novel coronavirus.

Can't be rushed

The 285,000-square foot research facility can house large animals, like bison and cattle, for testing. Scientists at VIDO-InterVacrecently developed a vaccine for a coronavirus that killed 10 million pigs in North America, andFalzarano uses alpacas to test vaccines that would combat the Middle East Respiratory Syndrome (MERS) coronavirus.

For this latest coronavirus, Falzarano expects to test a vaccine on ferrets, as researchers did with Severe Acute Respiratory Syndrome (SARS), the coronavirusthat infected about 8,000 people during the global outbreak of 2003.

Human trials for this latest coronavirus are at least a year away.Falzarano cautions that some things can't be rushed.

"Everyone can work as hardas they can, and as fast as they can, but certain processes take a certain amount of time and it's really hard to work faster than that," he said.

The team's research is part of a global effort says VIDO-InterVacexecutive director Volker Gerdts.

"I wouldn't say it's a race. I mean, right now, this disease is really a concern toeveryone on this planet," Gerdts said, adding thathis team will share their findings with other scientists.

'Prepare for the worst'

Researchers at VIDO-InterVac worked on a potential vaccine for SARS in 2003. But when cases disappeared, the funding dried up. Research never advanced to human trials.

Falzarano says researchers have to tackle this latest coronavirus as though it could turn into a pandemic.

"We don't know that this is a once-and-done scenario, so I think you always have to prepare for the worst case scenario," he said.

Falzarano says he doesn't think a SARS vaccine, if it had been developed, would be effective on this one.

However, those three strains of coronovirusthat can be deadly to humans have underscored the need for a "pan-coronavirus vaccine."

That's the ultimate goal of this research team. Scientists proposeusing structural biology and protein engineering to developwide-serving vaccines that could protect againstmultiple strains of coronaviruses.

Limited capacity

VIDO-InterVac's$18 million annual costs arefunded mostly by Ottawa and the province.

A vaccine development project can cost hundreds of thousands of dollars in the early phases, then millions as development nears the manufacturing phase.

VIDO-InterVac is both a research and development centre, butwork can stall when it's time to manufacture a vaccine, because of limited capacity.

"We don't have capacity in the country, or not as much as we used to have," Gerdts said."So when these situations like this one arise, we have to go to other countries to get our technologies manufactured in those countries.So it's really a bottleneck for public research like ours."

Gerdts wants to attract more government funding for VIDO-InterVac to add manufacturing into its operation.