Toronto's CAMH gets 1st federal grant to study magic mushrooms as treatment for depression

Toronto's Centre for Addiction and Mental Health (CAMH) says it has received the first-ever federal grant to study whether the active component in 'magic' mushroomscan be used to treat depression without the psychedelic effects.

Psilocybin is the chemical compound in magic mushrooms that induces a so-called 'trip.' Researchers at CAMHare going to explore if those psychoactive effects are necessary for the compound to alleviatetreatment-resistant depression in adults.

"There has been a growing interest and body of knowledge regarding the use of psychedelic drugs for the treatment of mental illness and addictions," said Dr. Ishrat Husain, lead investigator of the upcomingstudy, in a news release.

Husain noted that clinical trials suggest psilocybin, combined with intensivepsychotherapy, can produce "sustained antidepressant effects" in those living with severe depression.

LISTEN | Dr. Ishrat Husain and a psilocybin advocate discuss its potential as a treatment:

One issue, though, is that because it comes with psychoactive side effects, users need "time intensive and costly" support during the treatment, Husain said. But if the researchers at CAMH find psilocybin can still help people suffering from depression without the "trip,"then it would make the treatment far more practical.

The study will include 60 adults who have been living with depression for at least three years and haven't responded to alternative forms of treatment. A random third of those participants will get a full dose of psilocybinplus a blockerthat will stop the drug's psychedelic effects. Another 20will get psilocybin and a placebo, while the third group will be given a placebo and the blocker.

All of the participants will also receive 12 hours of psychotherapy "as per current practice in psychedelic research," the news release said.

The hope is the researchwill serve as a foundation for further clinical exploration ofpsilocybinas a treatment for depression without the need for psychotherapy.

CAMH'sstudyis being funded by the Canadian Institute for Health Research. The grant was awarded this month and, according to the hospital, is the first time the federal government has provided money for a study of this type.

It comes amid a growing wave of interest globally in potentially using psychedelics like psilocybin, ketamine,MDMA(the active ingredient in ecstasy)and LSDto treat mental illnesses, as well as a host of other medical conditions.

In its news release, CAMH stressed the need for well-designed clinical trials in pushing this kind of research forward, as approvals fromfederal authorities in Canadahave so far been been limited.

In 2020, Health Canada granted permission to16 health professionals to use psilocybinthemselves to help develop therapies for future use.

Earlier this year, though, the federal health minister rejected applications for more than 100 health-care practitioners including doctors, psychologists, clinical counsellors, social workers and nurses to use psychedelic drugs as part of psychotherapy treatments.

Meanwhile,Health Canada suspended a study into MDMA-assisted psychotherapythis summer over patient safety concerns.