Experimental Ebola vaccine passes 1st hurdle in U.S.

An experimental Ebola vaccine developed in the U.S. appears to be safe and promising in an early clinical trial, according to new findings.

The vaccine made by British pharmaceutical giant GlaxoSmithKline and the U.S. National Institutes of Health (NIH)is being developed to combat the Sudan and Zaire strains of the Ebola virus, the latter the one behind the current deadly outbreak in West Africa.

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The trials were conducted at the NIHin Bethesda, Md., with 20 healthy participants who received doses of the vaccine.

The participants developed antibodies to Ebola, researchers said in Wednesday's New England Journal of Medicine. But the researchers note participants' immune responses depended on the dose and were also associated with minor side-effects.

Clinical trials of the vaccine are continuing. The NIH is in talks with Liberian officials about doing the next tests in West Africa, though details have yet to be released.

The World Health Organization has said it hopes to begin testing experimental vaccinesas early as January on more than 20,000 front-line health-care workers and othersin West Africa's hot zone.

"Perhaps one of the only silver linings of the[Ebola]crisis that has shaken West Africa over thepast year is that the event has pushed therapeutics and vaccines for [Ebola], which had previouslybeen relatively stalled in development despite thepromising results in nonhuman primates, intoaccelerated production and clinical trials," Dr. Daniel Bausch, who is not one of the vaccine's researchers, wrote in an editorial published alongside the trial findings.

Meanwhile, a Canadian-developedEbola vaccineis also currently undergoing human clinical trials in Canada and the U.S., with additionaltests to be done in Germany, Switzerland, Gabon and Kenya.

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WHO reported on Wednesday that there have been 5,689 Ebola deaths out of nearly 16,000 cases.Almost all cases and all but 15 deaths have been in Guinea,Sierra Leone and Liberia the three hardest-hit countries,which reported 600 new cases in the past week.